Mortality of Altitude-exposed Mice Infected with Pasturella tularensis
نویسندگان
چکیده
منابع مشابه
Immunization of Mice with Irradiated Pasteurella Tularensis.
Viable attenuated tularemia vaccines have been shown to bt. effective in immunizing mice and other animals against challenge with high].y virulent Pasteurella tularensis. Nonviable preparations, however, induced little or no resistance to challenge with even small numbers of virulent organisms. It seemed reasonable to expect that antigenicity would be retained to a greater extent if the organis...
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Francisella tularensis is a category A select agent based on its infectivity and virulence but disease mechanisms in infection remain poorly understood. Murine pulmonary models of infection were therefore employed to assess and compare dissemination and pathology and to elucidate the host immune response to infection with the highly virulent Type A F. tularensis strain Schu4 versus the less vir...
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We investigated the immune response induced by the Francisella (F.) tularensis live vaccine strain (LVS) and the Pohang isolate. After the Balb/c mice were infected intradermally (i.d) with 2 x 10(4) cfu of F. tularensis LVS and Pohang, respectively, their blood and organs were collected at different times; 0, 3, 6, 24, 72, 96, 120 and 168 h after infection. Using these samples, RT-PCR and ELIS...
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Francisella tularensis subspecies tularensis (type A) and holarctica (type B) are of clinical importance in causing tularemia. Molecular typing methods have further separated type A strains into three genetically distinct clades, A1a, A1b and A2. Epidemiological analyses of human infections in the United States suggest that A1b infections are associated with a significantly higher mortality rat...
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ژورنال
عنوان ژورنال: Applied Microbiology
سال: 1968
ISSN: 0003-6919
DOI: 10.1128/aem.16.10.1451-1453.1968